| 6. Jornada | 22.08.2021 | Pumas UNAM [Sub 18] | - | Puebla FC [Sub 18] | 3:3 |  |
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| 8. Jornada | 12.09.2021 | Pumas UNAM [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 1:1 |  |
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| 9. Jornada | 18.09.2021 | Mazatlán FC [Sub 18] | - | Pumas UNAM [Sub 18] | 2:0 | ||||
| 12. Jornada | 03.10.2021 | CF América [Sub 18] | - | Pumas UNAM [Sub 18] | 1:0 |  |
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| 11. Jornada | 04.11.2021 | Pumas UNAM [Sub 18] | - | Santos Laguna [Sub 18] | 0:1 | ||||
| 17. Jornada | 07.11.2021 | Pumas UNAM [Sub 18] | - | Cruz Azul [Sub 18] | 2:2 | |
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México