| 1. Jornada | 12.08.2021 | Balzan FC | - | Sliema Wanderers | 1:0 | ||||
| 3. Jornada | 11.09.2021 | Gżira United | - | Sliema Wanderers | 1:1 |  |
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| 4. Jornada | 19.09.2021 | Sliema Wanderers | - | Gudja United | 2:3 | |
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| 6. Jornada | 17.10.2021 | Sliema Wanderers | - | Hibernians FC | 0:3 | ||||
| 8. Jornada | 31.10.2021 | Sliema Wanderers | - | Mosta FC | 2:3 | |
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| 10. Jornada | 27.11.2021 | Birkirkara FC | - | Sliema Wanderers | 2:0 | ||||
| 11. Jornada | 05.12.2021 | Sliema Wanderers | - | Hamrun Spartans | 0:2 |
Portugal