| 1. Jornada | 21.01.2022 | H&H Export Sébaco | - | Real Estelí FC | 4:4 | ||||
| 2. Jornada | 07.02.2022 | H&H Export Sébaco | - | UNAN Managua | 1:1 | ||||
| 3. Jornada | 11.02.2022 | Club Deportivo Ocotal | - | H&H Export Sébaco | 0:0 |  |
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| 4. Jornada | 14.02.2022 | Managua FC | - | H&H Export Sébaco | 3:2 | ||||
| 5. Jornada | 20.02.2022 | Juventus Managua | - | H&H Export Sébaco | 5:1 | ||||
| 6. Jornada | 27.02.2022 | CD Walter Ferretti | - | H&H Export Sébaco | 5:0 | |
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| 8. Jornada | 05.03.2022 | H&H Export Sébaco | - | Diriangén FC | 4:0 | ||||
| 9. Jornada | 09.03.2022 | H&H Export Sébaco | - | Real Madriz | 1:1 | ||||
| 10. Jornada | 14.03.2022 | Real Estelí FC | - | H&H Export Sébaco | 3:3 | ||||
| 11. Jornada | 19.03.2022 | UNAN Managua | - | H&H Export Sébaco | 3:3 |  |
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| 12. Jornada | 03.04.2022 | H&H Export Sébaco | - | Club Deportivo Ocotal | 4:1 | |
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| 14. Jornada | 09.04.2022 | H&H Export Sébaco | - | Juventus Managua | 2:0 | |
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| 15. Jornada | 14.04.2022 | ART Municipal Jalapa | - | H&H Export Sébaco | 1:0 | ||||
| 16. Jornada | 24.04.2022 | H&H Export Sébaco | - | CD Walter Ferretti | 2:0 | ||||
| 17. Jornada | 29.04.2022 | Diriangén FC | - | H&H Export Sébaco | 8:0 | ||||
| 18. Jornada | 02.05.2022 | Real Madriz | - | H&H Export Sébaco | 0:0 |
Argentina