| 2. Jornada | 21.08.2021 | NK Opatija | - | NK Inter Zaprešić | 3:0 | ||||
| 3. Jornada | 28.08.2021 | NK Kustošija | - | NK Opatija | 0:0 | ||||
| 5. Jornada | 15.09.2021 | Dinamo Zagreb II | - | NK Opatija | 2:1 | ||||
| 6. Jornada | 18.09.2021 | NK Opatija | - | NK Solin | 1:1 |  |
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| 7. Jornada | 26.09.2021 | NK Croatia Zmijavci | - | NK Opatija | 3:0 | ||||
| 8. Jornada | 02.10.2021 | NK Osijek II | - | NK Opatija | 0:2 | ||||
| 9. Jornada | 16.10.2021 | NK Opatija | - | NK Varaždin | 2:2 | ||||
| 10. Jornada | 23.10.2021 | NK Rudeš | - | NK Opatija | 3:0 | ||||
| 11. Jornada | 30.10.2021 | NK Opatija | - | NK Jarun | 0:1 | ||||
| 13. Jornada | 20.11.2021 | NK Opatija | - | NK Dugopolje | 0:2 | ||||
| 14. Jornada | 27.11.2021 | NK Dubrava | - | NK Opatija | 1:0 | ||||
| 15. Jornada | 04.12.2021 | NK Opatija | - | HNK Orijent Rijeka | 0:1 | |
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| 16. Jornada | 12.02.2022 | NK Opatija | - | HNK Cibalia | 2:1 | ||||
| 17. Jornada | 18.02.2022 | NK Inter Zaprešić | - | NK Opatija | 1:0 | |
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| 19. Jornada | 06.03.2022 | NK BSK Bijelo Brdo | - | NK Opatija | 4:1 |
Croacia