| 1. Jornada | 18.07.2021 | Spartak Subotica | - | Radnički Niš | 1:1 | ||||
| 2. Jornada | 23.07.2021 | FK Radnički 1923 | - | Spartak Subotica | 3:2 | ||||
| 3. Jornada | 31.07.2021 | Spartak Subotica | - | Crvena Zvezda | 1:3 | ||||
| 4. Jornada | 07.08.2021 | Mladost Lučani | - | Spartak Subotica | 1:2 | ||||
| 5. Jornada | 16.08.2021 | Spartak Subotica | - | Vojvodina | 2:2 |  |
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| 6. Jornada | 22.08.2021 | Spartak Subotica | - | FK Napredak | 3:2 | ||||
| 7. Jornada | 28.08.2021 | Radnik Surdulica | - | Spartak Subotica | 1:2 |  |
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| 12. Jornada | 02.10.2021 | Spartak Subotica | - | FK Voždovac | 0:4 | ||||
| 15. Jornada | 02.11.2021 | FK Kolubara | - | Spartak Subotica | 1:2 | ||||
| 16. Jornada | 07.11.2021 | Radnički Niš | - | Spartak Subotica | 0:0 | ||||
| 17. Jornada | 21.11.2021 | Spartak Subotica | - | FK Radnički 1923 | 1:1 | ||||
| 18. Jornada | 28.11.2021 | Crvena Zvezda | - | Spartak Subotica | 3:0 | ||||
| 19. Jornada | 05.12.2021 | Spartak Subotica | - | Mladost Lučani | 0:0 | ||||
| 21. Jornada | 18.12.2021 | FK Napredak | - | Spartak Subotica | 1:0 |
Serbia