| 3. Jornada | 17.08.2021 | Colchester United | - | Mansfield Town | 1:1 | ||||
| 4. Jornada | 21.08.2021 | Oldham Athletic | - | Colchester United | 1:2 | ||||
| 5. Jornada | 27.08.2021 | Rochdale AFC | - | Colchester United | 1:1 |  |
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| 14. Jornada | 23.10.2021 | Port Vale FC | - | Colchester United | 3:0 | ||||
| 6. Jornada | 26.10.2021 | Colchester United | - | Sutton United | 1:3 | ||||
| 15. Jornada | 30.10.2021 | Colchester United | - | Scunthorpe United | 2:1 | ||||
| 27. Jornada | 15.01.2022 | Colchester United | - | Barrow AFC | 0:2 | ||||
| 24. Jornada | 18.01.2022 | Sutton United | - | Colchester United | 3:2 | ||||
| 30. Jornada | 05.02.2022 | Leyton Orient | - | Colchester United | 0:1 | |
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| 36. Jornada | 12.03.2022 | Scunthorpe United | - | Colchester United | 1:3 | ||||
| 40. Jornada | 02.04.2022 | Harrogate Town | - | Colchester United | 1:2 | ||||
| 43. Jornada | 18.04.2022 | Colchester United | - | Bradford City | 3:0 |
Inglaterra