| 19. Jornada | 26.02.2022 | FK Nizhny Novgorod | - | FK Ural | 1:0 | ||||
| 20. Jornada | 05.03.2022 | CSKA Moscú | - | FK Nizhny Novgorod | 1:0 | ||||
| 21. Jornada | 12.03.2022 | FK Ufa | - | FK Nizhny Novgorod | 0:0 | ||||
| 24. Jornada | 09.04.2022 | FK Nizhny Novgorod | - | Dinamo Moskva | 0:1 |  |
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| 25. Jornada | 17.04.2022 | FK Nizhny Novgorod | - | FK Khimki | 0:0 | ||||
| 27. Jornada | 02.05.2022 | Arsenal Tula | - | FK Nizhny Novgorod | 2:2 | ||||
| 28. Jornada | 07.05.2022 | FK Nizhny Novgorod | - | Akhmat Grozny | 0:1 |
Angola