| 1. Jornada | 23.01.2022 | Valledupar FC | - | Real Santander | 1:0 |  |
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| 2. Jornada | 29.01.2022 | Atlético FC | - | Valledupar FC | 0:0 | ||||
| 3. Jornada | 06.02.2022 | Valledupar FC | - | Leones FC | 0:1 | |
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| 4. Jornada | 15.02.2022 | Bogotá FC | - | Valledupar FC | 2:1 | |
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| 5. Jornada | 20.02.2022 | Valledupar FC | - | Orsomarso SC | 2:0 |  |
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| 6. Jornada | 26.02.2022 | Llaneros FC | - | Valledupar FC | 0:0 | |
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| 7. Jornada | 07.03.2022 | Valledupar FC | - | Deportes Quindío | 0:0 | ||||
| 8. Jornada | 11.03.2022 | Boyacá Chicó | - | Valledupar FC | 2:2 | |
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| 9. Jornada | 20.03.2022 | Valledupar FC | - | Boca Juniors de Cali | 2:1 | |
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| 15. Jornada | 04.05.2022 | Real Cartagena | - | Valledupar FC | 1:2 | |
Colombia