| 1. Jornada | 14.08.2021 | Heracles Almelo | - | PSV | 0:2 | ||||
| 2. Jornada | 21.08.2021 | Sparta Rotterdam | - | Heracles Almelo | 1:1 | ||||
| 3. Jornada | 29.08.2021 | Heracles Almelo | - | NEC Nijmegen | 0:1 | ||||
| 5. Jornada | 19.09.2021 | Heracles Almelo | - | AZ Alkmaar | 3:2 | ||||
| 6. Jornada | 23.09.2021 | SC Cambuur | - | Heracles Almelo | 2:1 | ||||
| 7. Jornada | 26.09.2021 | Heracles Almelo | - | RKC Waalwijk | 1:0 | ||||
| 9. Jornada | 16.10.2021 | Go Ahead Eagles | - | Heracles Almelo | 4:2 | ||||
| 15. Jornada | 04.12.2021 | Heracles Almelo | - | sc Heerenveen | 0:1 |
Bélgica