| 1. Jornada | 26.10.2021 | Zamalek | - | ENPPI | 2:0 | ||||
| 2. Jornada | 31.10.2021 | Tala'ea El Gaish SC | - | Zamalek | 0:2 | ||||
| 3. Jornada | 05.11.2021 | Zamalek | - | Al Ahly SC | 3:5 | ||||
| 4. Jornada | 19.11.2021 | Ismaily | - | Zamalek | 0:2 | ||||
| 5. Jornada | 22.11.2021 | Zamalek | - | National Bank SC | 1:1 | ||||
| 6. Jornada | 25.11.2021 | Ceramica Cleopatra | - | Zamalek | 0:1 | ||||
| 7. Jornada | 21.12.2021 | Al Mokawloon | - | Zamalek | 1:2 |  |
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| 8. Jornada | 25.12.2021 | Zamalek | - | Ghazl Al Mehalla | 4:0 | |
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| 9. Jornada | 15.02.2022 | Smouha Sporting Club | - | Zamalek | 2:0 | ||||
| 19. Jornada | 17.05.2022 | Zamalek | - | Tala'ea El Gaish SC | 0:1 | ||||
| 21. Jornada | 28.05.2022 | Zamalek | - | Ismaily | 2:1 | ||||
| 20. Jornada | 19.06.2022 | Al Ahly SC | - | Zamalek | 2:2 | ||||
| 22. Jornada | 22.06.2022 | National Bank SC | - | Zamalek | 1:2 | ||||
| 23. Jornada | 28.06.2022 | Zamalek | - | Ceramica Cleopatra | 3:2 | ||||
| 24. Jornada | 12.07.2022 | Zamalek | - | Al Mokawloon | 1:0 |  |
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| 25. Jornada | 16.07.2022 | Ghazl Al Mehalla | - | Zamalek | 0:2 |
Marruecos