| 2. Jornada | 30.10.2021 | ENPPI | - | Al Mokawloon | 3:2 |  |
 |
||
| 3. Jornada | 04.11.2021 | Al Mokawloon | - | Tala'ea El Gaish SC | 1:1 | ||||
| 4. Jornada | 19.11.2021 | Al Ahly SC | - | Al Mokawloon | 1:0 | ||||
| 5. Jornada | 23.11.2021 | Al Mokawloon | - | Ismaily | 1:1 | |
|||
| 6. Jornada | 26.11.2021 | National Bank SC | - | Al Mokawloon | 2:1 | ||||
| 7. Jornada | 21.12.2021 | Al Mokawloon | - | Zamalek | 1:2 | |
|
||
| 9. Jornada | 15.02.2022 | Ghazl Al Mehalla | - | Al Mokawloon | 1:1 | ||||
| 10. Jornada | 21.02.2022 | Al Mokawloon | - | Smouha Sporting Club | 0:0 | ||||
| 11. Jornada | 25.02.2022 | Future FC | - | Al Mokawloon | 1:0 | ||||
| 12. Jornada | 04.03.2022 | Al Mokawloon | - | Pyramids FC | 0:2 | ||||
| 19. Jornada | 15.05.2022 | Al Mokawloon | - | ENPPI | 2:2 | ||||
| 20. Jornada | 21.05.2022 | Tala'ea El Gaish SC | - | Al Mokawloon | 1:0 | ||||
| 23. Jornada | 28.06.2022 | Al Mokawloon | - | National Bank SC | 1:1 | ||||
| 26. Jornada | 22.07.2022 | Al Mokawloon | - | Ghazl Al Mehalla | 1:0 | |
|||
| 27. Jornada | 27.07.2022 | Smouha Sporting Club | - | Al Mokawloon | 1:1 | ||||
| 21. Jornada | 30.07.2022 | Al Mokawloon | - | Al Ahly SC | 0:0 | ||||
| 28. Jornada | 02.08.2022 | Al Mokawloon | - | Future FC | 0:1 | ||||
| 29. Jornada | 06.08.2022 | Pyramids FC | - | Al Mokawloon | 1:0 |
Egipto