| 6. Jornada | 21.09.2021 | Fortuna Sittard | - | AFC Ajax | 0:5 |  |
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| 7. Jornada | 25.09.2021 | AFC Ajax | - | FC Groningen | 3:0 | ||||
| 9. Jornada | 16.10.2021 | sc Heerenveen | - | AFC Ajax | 0:2 | ||||
| 10. Jornada | 24.10.2021 | AFC Ajax | - | PSV | 5:0 | ||||
| 12. Jornada | 07.11.2021 | AFC Ajax | - | Go Ahead Eagles | 0:0 | ||||
| 22. Jornada | 13.02.2022 | AFC Ajax | - | FC Twente | 5:0 | ||||
| 24. Jornada | 27.02.2022 | Go Ahead Eagles | - | AFC Ajax | 2:1 | ||||
| 25. Jornada | 06.03.2022 | AFC Ajax | - | RKC Waalwijk | 3:2 | ||||
| 26. Jornada | 11.03.2022 | SC Cambuur | - | AFC Ajax | 2:3 | ||||
| 28. Jornada | 02.04.2022 | FC Groningen | - | AFC Ajax | 1:3 | ||||
| 29. Jornada | 09.04.2022 | AFC Ajax | - | Sparta Rotterdam | 2:1 | ||||
| 30. Jornada | 23.04.2022 | NEC Nijmegen | - | AFC Ajax | 0:1 | ||||
| 31. Jornada | 30.04.2022 | AFC Ajax | - | PEC Zwolle | 3:0 | ||||
| 32. Jornada | 08.05.2022 | AZ Alkmaar | - | AFC Ajax | 2:2 | ||||
| 33. Jornada | 11.05.2022 | AFC Ajax | - | sc Heerenveen | 5:0 | ||||
| 34. Jornada | 15.05.2022 | Vitesse | - | AFC Ajax | 2:2 |
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