| 24. Jornada | 14.02.2021 | Southampton | - | Wolverhampton Wanderers | 1:2 | ||||
| 25. Jornada | 20.02.2021 | Southampton | - | Chelsea | 1:1 | ||||
| 18. Jornada | 23.02.2021 | Leeds United | - | Southampton | 3:0 | ||||
| 26. Jornada | 01.03.2021 | Everton | - | Southampton | 1:0 | ||||
| 33. Jornada | 10.03.2021 | Manchester City | - | Southampton | 5:2 | ||||
| 30. Jornada | 04.04.2021 | Southampton | - | Burnley FC | 3:2 | ||||
| 29. Jornada | 21.04.2021 | Tottenham Hotspur | - | Southampton | 2:1 | ||||
| 34. Jornada | 30.04.2021 | Southampton | - | Leicester City | 1:1 | ||||
| 32. Jornada | 11.05.2021 | Southampton | - | Crystal Palace | 3:1 | ||||
| 36. Jornada | 15.05.2021 | Southampton | - | Fulham FC | 3:1 | ||||
| 37. Jornada | 18.05.2021 | Southampton | - | Leeds United | 0:2 | ||||
| 38. Jornada | 23.05.2021 | West Ham United | - | Southampton | 3:0 |  |
Ghana