| 14. Jornada | 20.10.2021 | Club León [Sub 20] | - | Pumas UNAM [Sub 20] | 0:2 | ||||
| 15. Jornada | 23.10.2021 | Puebla FC [Sub 20] | - | Club León [Sub 20] | 2:1 | ||||
| 16. Jornada | 31.10.2021 | Deportivo Toluca [Sub 20] | - | Club León [Sub 20] | 1:0 | ||||
| 17. Jornada | 06.11.2021 | Club León [Sub 20] | - | Club Necaxa [Sub 20] | 3:1 |
México