| 3. Jornada | 08.08.2021 | FK Pardubice | - | FK Mladá Boleslav | 1:1 | ||||
| 4. Jornada | 15.08.2021 | Baník Ostrava | - | FK Pardubice | 3:1 |  |
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| 5. Jornada | 21.08.2021 | FK Pardubice | - | Bohemians Praha 1905 | 3:0 |  |
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| 6. Jornada | 28.08.2021 | 1. FC Slovácko | - | FK Pardubice | 2:1 | ||||
| 7. Jornada | 11.09.2021 | FK Pardubice | - | Slovan Liberec | 2:2 | ||||
| 8. Jornada | 17.09.2021 | FC Hradec Králové | - | FK Pardubice | 2:0 | ||||
| 9. Jornada | 25.09.2021 | FK Pardubice | - | Viktoria Plzeň | 0:1 | ||||
| 10. Jornada | 02.10.2021 | Dynamo České Budějovice | - | FK Pardubice | 3:1 | ||||
| 11. Jornada | 17.10.2021 | FK Pardubice | - | Sparta Praga | 2:4 | ||||
| 12. Jornada | 23.10.2021 | FK Pardubice | - | FC Fastav Zlín | 0:0 | ||||
| 13. Jornada | 31.10.2021 | FK Jablonec | - | FK Pardubice | 1:1 | ||||
| 14. Jornada | 07.11.2021 | FK Pardubice | - | Slavia Praga | 0:5 | ||||
| 15. Jornada | 21.11.2021 | FK Teplice | - | FK Pardubice | 1:2 | |
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| 17. Jornada | 05.12.2021 | FK Mladá Boleslav | - | FK Pardubice | 2:3 | |
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| 18. Jornada | 11.12.2021 | FK Pardubice | - | Baník Ostrava | 0:3 | ||||
| 19. Jornada | 18.12.2021 | Bohemians Praha 1905 | - | FK Pardubice | 1:2 | |
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