| 2. Jornada | 15.01.2022 | Atlas Guadalajara [] | - | Club Tijuana [] | 1:2 | ||||
| 3. Jornada | 22.01.2022 | Atlas Guadalajara [] | - | CF Monterrey [] | 2:1 | ||||
| 4. Jornada | 29.01.2022 | Atlético San Luis [] | - | Atlas Guadalajara [] | 0:2 | ||||
| 6. Jornada | 12.02.2022 | Santos Laguna [] | - | Atlas Guadalajara [] | 4:3 |  |
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| 7. Jornada | 19.02.2022 | Atlas Guadalajara [] | - | UANL Tigres [] | 5:2 | ||||
| 10. Jornada | 12.03.2022 | Atlas Guadalajara [] | - | Santos Laguna [] | 3:0 | ||||
| 11. Jornada | 19.03.2022 | CF Monterrey [] | - | Atlas Guadalajara [] | 1:1 | ||||
| 15. Jornada | 16.04.2022 | Atlas Guadalajara [] | - | Mazatlán FC [] | 5:1 | ||||
| 16. Jornada | 23.04.2022 | Atlas Guadalajara [] | - | Deportivo Guadalajara [] | 2:1 |
México