| 2. Jornada | 14.08.2021 | Port Vale FC | - | Tranmere Rovers | 0:0 | ||||
| 3. Jornada | 17.08.2021 | Swindon Town | - | Tranmere Rovers | 0:0 |  |
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| 4. Jornada | 21.08.2021 | Tranmere Rovers | - | Newport County | 0:1 | ||||
| 5. Jornada | 28.08.2021 | Scunthorpe United | - | Tranmere Rovers | 1:0 | |
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| 6. Jornada | 04.09.2021 | Tranmere Rovers | - | Hartlepool United | 1:0 | |
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| 7. Jornada | 11.09.2021 | Rochdale AFC | - | Tranmere Rovers | 1:0 | ||||
| 8. Jornada | 18.09.2021 | Tranmere Rovers | - | Salford City | 2:0 | ||||
| 16. Jornada | 13.11.2021 | Tranmere Rovers | - | Sutton United | 0:1 | |
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| 17. Jornada | 20.11.2021 | Bristol Rovers | - | Tranmere Rovers | 2:2 | |
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| 18. Jornada | 23.11.2021 | Tranmere Rovers | - | Bradford City | 2:1 | ||||
| 29. Jornada | 29.01.2022 | Tranmere Rovers | - | Forest Green Rovers | 0:4 | ||||
| 19. Jornada | 01.02.2022 | Tranmere Rovers | - | Stevenage FC | 1:0 | ||||
| 30. Jornada | 05.02.2022 | Barrow AFC | - | Tranmere Rovers | 1:1 | ||||
| 35. Jornada | 05.03.2022 | Northampton Town | - | Tranmere Rovers | 3:2 | ||||
| 40. Jornada | 02.04.2022 | Tranmere Rovers | - | Carlisle United | 2:2 | ||||
| 41. Jornada | 09.04.2022 | Tranmere Rovers | - | Bristol Rovers | 1:1 |
Inglaterra