| 5. Jornada | 06.03.2022 | Newell's Old Boys | - | Atlético Tucumán | 4:0 |  |
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| 6. Jornada | 12.03.2022 | Sarmiento de Junín | - | Newell's Old Boys | 2:2 | ||||
| 7. Jornada | 20.03.2022 | Rosario Central | - | Newell's Old Boys | 0:1 | ||||
| 8. Jornada | 04.04.2022 | Newell's Old Boys | - | Platense | 3:1 | ||||
| 9. Jornada | 09.04.2022 | Unión de Santa Fe | - | Newell's Old Boys | 1:0 | ||||
| 12. Jornada | 24.04.2022 | Racing Club | - | Newell's Old Boys | 0:0 | ||||
| 13. Jornada | 28.04.2022 | Newell's Old Boys | - | San Lorenzo | 1:2 |
Argentina