| 1. Jornada | 12.02.2021 | Vélez Sarsfield II | - | Newell's Old Boys II | 3:0 | ||||
| 2. Jornada | 19.02.2021 | Newell's Old Boys II | - | Boca Juniors II | 1:3 |  |
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| 3. Jornada | 26.02.2021 | Talleres de Córdoba II | - | Newell's Old Boys II | 2:2 | ||||
| 4. Jornada | 05.03.2021 | Newell's Old Boys II | - | Independiente II | 1:2 | ||||
| 5. Jornada | 12.03.2021 | Defensa y Justicia II | - | Newell's Old Boys II | 2:1 | ||||
| 6. Jornada | 19.03.2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 3:1 | ||||
| 7. Jornada | 26.03.2021 | Atlético Tucumán II | - | Newell's Old Boys II | 0:1 | |
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| 8. Jornada | 02.04.2021 | Newell's Old Boys II | - | Huracán II | 3:0 | |
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| 10. Jornada | 16.04.2021 | Newell's Old Boys II | - | Patronato de Paraná II | 1:0 | ||||
| 11. Jornada | 23.04.2021 | Gimnasia de La Plata II | - | Newell's Old Boys II | 0:0 | ||||
| 12. Jornada | 30.04.2021 | Rosario Central II | - | Newell's Old Boys II | 0:2 | |
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| 13. Jornada | 07.05.2021 | Newell's Old Boys II | - | Sarmiento de Junín II | 6:2 | |
Argentina