| 1. Jornada | 16.07.2021 | Newell's Old Boys II | - | Talleres de Córdoba II | 2:1 | ||||
| 2. Jornada | 23.07.2021 | Argentinos Juniors II | - | Newell's Old Boys II | 3:1 | ||||
| 3. Jornada | 27.07.2021 | Newell's Old Boys II | - | Estudiantes II | 1:3 | ||||
| 5. Jornada | 06.08.2021 | Newell's Old Boys II | - | Platense II | 1:2 |  |
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| 6. Jornada | 16.08.2021 | Racing Club II | - | Newell's Old Boys II | 1:1 | ||||
| 8. Jornada | 24.08.2021 | Defensa y Justicia II | - | Newell's Old Boys II | 1:1 | ||||
| 16. Jornada | 14.10.2021 | Gimnasia de La Plata II | - | Newell's Old Boys II | 1:1 | ||||
| 17. Jornada | 18.10.2021 | Newell's Old Boys II | - | Aldosivi II | 1:0 | ||||
| 21. Jornada | 17.11.2021 | Arsenal de Sarandí II | - | Newell's Old Boys II | 0:3 | |
Argentina