| 1. Jornada | 18.09.2021 | Club Necaxa [] | - | Santos Laguna [] | 4:0 | ||||
| 2. Jornada | 25.09.2021 | Santos Laguna [] | - | Atlas Guadalajara [] | 2:0 | ||||
| 3. Jornada | 02.10.2021 | Atlético San Luis [] | - | Santos Laguna [] | 1:1 | ||||
| 4. Jornada | 09.10.2021 | Mazatlán FC [] | - | Santos Laguna [] | 0:2 |  |
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| 5. Jornada | 16.10.2021 | Santos Laguna [] | - | CF Monterrey [] | 4:1 |  |
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| 7. Jornada | 30.10.2021 | Santos Laguna [] | - | Club Necaxa [] | 0:2 | ||||
| 8. Jornada | 05.11.2021 | UANL Tigres [] | - | Santos Laguna [] | 3:1 | ||||
| 9. Jornada | 13.11.2021 | Santos Laguna [] | - | Deportivo Guadalajara [] | 0:2 | ||||
| 10. Jornada | 20.11.2021 | Club León [] | - | Santos Laguna [] | 4:2 | |
México