| 1. Jornada | 07.03.2010 | Club San José | - | CD Guabirá | 3:0 |  |
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| 2. Jornada | 14.03.2010 | Club San José | - | The Strongest | 2:2 | ||||
| 3. Jornada | 19.03.2010 | Blooming | - | Club San José | 1:3 | |
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| 4. Jornada | 21.03.2010 | Club San José | - | Club Aurora | 0:1 | ||||
| 5. Jornada | 27.03.2010 | La Paz FC | - | Club San José | 4:2 | |
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| 6. Jornada | 02.04.2010 | Universitario de Sucre | - | Club San José | 2:3 | ||||
| 7. Jornada | 11.04.2010 | CD Guabirá | - | Club San José | 1:1 | ||||
| 9. Jornada | 24.04.2010 | Club San José | - | La Paz FC | 4:2 | ||||
| 10. Jornada | 29.04.2010 | Club San José | - | Blooming | 3:1 | ||||
| 11. Jornada | 02.05.2010 | Club Aurora | - | Club San José | 2:1 | |
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| 12. Jornada | 07.05.2010 | Club San José | - | Universitario de Sucre | 0:0 |
Paraguay