| 1. Jornada | 17.04.2021 | CF Montréal | - | Toronto FC | 4:2 | ||||
| 1. Jornada | 24.04.2021 | Toronto FC | - | Vancouver Whitecaps | 2:2 | ||||
| 2. Jornada | 08.05.2021 | New York RB | - | Toronto FC | 2:0 | ||||
| 2. Jornada | 13.05.2021 | Toronto FC | - | Columbus Crew | 2:0 | ||||
| 2. Jornada | 15.05.2021 | New York City FC | - | Toronto FC | 1:1 | ||||
| 2. Jornada | 23.05.2021 | Orlando City | - | Toronto FC | 1:0 | ||||
| 2. Jornada | 29.05.2021 | Columbus Crew | - | Toronto FC | 2:1 | ||||
| 4. Jornada | 08.07.2021 | New England Revolution | - | Toronto FC | 2:3 | ||||
| 4. Jornada | 25.07.2021 | Chicago Fire | - | Toronto FC | 1:2 |  |
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| 5. Jornada | 05.08.2021 | Philadelphia Union | - | Toronto FC | 3:0 | ||||
| 5. Jornada | 08.08.2021 | Toronto FC | - | New York City FC | 2:2 | ||||
| 5. Jornada | 15.08.2021 | Toronto FC | - | New England Revolution | 1:2 | ||||
| 5. Jornada | 22.08.2021 | Inter Miami CF | - | Toronto FC | 3:1 | ||||
| 6. Jornada | 12.09.2021 | FC Cincinnati | - | Toronto FC | 2:0 | ||||
| 7. Jornada | 31.10.2021 | Atlanta United FC | - | Toronto FC | 1:1 |  |
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| 8. Jornada | 07.11.2021 | Toronto FC | - | D.C. United | 1:3 |
Estados Unidos
Trinidad y Tobago 