| 1. Jornada | 17.01.2010 | Puebla FC | - | UANL Tigres | 0:1 |  |
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| 3. Jornada | 31.01.2010 | Puebla FC | - | Gallos Blancos (old) | 1:2 | |
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| 4. Jornada | 07.02.2010 | Atlante | - | Puebla FC | 1:1 | |
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| 5. Jornada | 14.02.2010 | Puebla FC | - | CF Pachuca | 3:5 | ||||
| 6. Jornada | 18.02.2010 | Puebla FC | - | Club San Luis | 1:0 | ||||
| 7. Jornada | 21.02.2010 | Deportivo Guadalajara | - | Puebla FC | 3:2 | ||||
| 9. Jornada | 07.03.2010 | Pumas UNAM | - | Puebla FC | 4:1 | ||||
| 10. Jornada | 14.03.2010 | Puebla FC | - | CF Monterrey | 1:1 | ||||
| 11. Jornada | 21.03.2010 | Santos Laguna | - | Puebla FC | 2:1 | ||||
| 12. Jornada | 29.03.2010 | Puebla FC | - | CF América | 2:1 | ||||
| 13. Jornada | 04.04.2010 | Monarcas Morelia | - | Puebla FC | 1:1 | |
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| 14. Jornada | 11.04.2010 | Puebla FC | - | Indios Juárez | 1:2 | ||||
| 15. Jornada | 15.04.2010 | Atlas Guadalajara | - | Puebla FC | 0:2 |  |
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| 16. Jornada | 18.04.2010 | Puebla FC | - | Cruz Azul | 4:1 | ||||
| 17. Jornada | 25.04.2010 | Deportivo Toluca | - | Puebla FC | 2:1 |
Uruguay