| 1. Jornada | 25.07.2021 | FC Fastav Zlín | - | Slavia Praga | 0:1 | ||||
| 2. Jornada | 30.07.2021 | FK Teplice | - | Slavia Praga | 1:3 | ||||
| 4. Jornada | 14.08.2021 | FK Mladá Boleslav | - | Slavia Praga | 0:2 | ||||
| 7. Jornada | 12.09.2021 | Slavia Praga | - | 1. FC Slovácko | 2:1 | ||||
| 8. Jornada | 19.09.2021 | Bohemians Praha 1905 | - | Slavia Praga | 1:5 |  |
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| 9. Jornada | 26.09.2021 | Slavia Praga | - | FC Hradec Králové | 4:1 | ||||
| 10. Jornada | 03.10.2021 | Sparta Praga | - | Slavia Praga | 1:0 | ||||
| 11. Jornada | 16.10.2021 | Slavia Praga | - | Slovan Liberec | 3:1 |  |
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| 3. Jornada | 27.10.2021 | Slavia Praga | - | Sigma Olomouc | 1:0 | ||||
| 13. Jornada | 31.10.2021 | Slavia Praga | - | Viktoria Plzeň | 2:0 | ||||
| 14. Jornada | 07.11.2021 | FK Pardubice | - | Slavia Praga | 0:5 | ||||
| 15. Jornada | 21.11.2021 | Slavia Praga | - | FK Jablonec | 5:0 | ||||
| 16. Jornada | 28.11.2021 | Slavia Praga | - | FK Teplice | 3:0 | |
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| 17. Jornada | 04.12.2021 | Sigma Olomouc | - | Slavia Praga | 0:1 | ||||
| 18. Jornada | 12.12.2021 | Slavia Praga | - | FK Mladá Boleslav | 2:0 | |
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| 19. Jornada | 19.12.2021 | Baník Ostrava | - | Slavia Praga | 3:3 |
Rumania