| 2. Jornada | 13.01.2023 | Atlas Guadalajara | - | Mazatlán FC | 2:1 |  |
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| 3. Jornada | 21.01.2023 | Mazatlán FC | - | Santos Laguna | 1:2 | ||||
| 4. Jornada | 29.01.2023 | CF América | - | Mazatlán FC | 6:0 | ||||
| 7. Jornada | 17.02.2023 | Mazatlán FC | - | CF Pachuca | 2:3 | ||||
| 8. Jornada | 20.02.2023 | Gallos Blancos | - | Mazatlán FC | 1:1 | |
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| 9. Jornada | 25.02.2023 | Mazatlán FC | - | Pumas UNAM | 1:2 | |
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| 10. Jornada | 04.03.2023 | Mazatlán FC | - | Cruz Azul | 3:1 | ||||
| 11. Jornada | 12.03.2023 | Deportivo Toluca | - | Mazatlán FC | 4:1 | |
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| 13. Jornada | 03.04.2023 | Atlético San Luis | - | Mazatlán FC | 2:1 | ||||
| 14. Jornada | 09.04.2023 | UANL Tigres | - | Mazatlán FC | 1:2 | ||||
| 15. Jornada | 15.04.2023 | Mazatlán FC | - | Club Tijuana | 1:2 | ||||
| 16. Jornada | 22.04.2023 | Mazatlán FC | - | CF Monterrey | 0:2 | ||||
| 17. Jornada | 30.04.2023 | Deportivo Guadalajara | - | Mazatlán FC | 4:1 |
Colombia
