| 5. Jornada | 16.08.2021 | Portland Timbers | - | Seattle Sounders | 2:6 |  |
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| 5. Jornada | 19.08.2021 | FC Dallas | - | Seattle Sounders | 0:1 | ||||
| 5. Jornada | 21.08.2021 | Columbus Crew | - | Seattle Sounders | 1:2 | ||||
| 5. Jornada | 30.08.2021 | Seattle Sounders | - | Portland Timbers | 0:2 | ||||
| 6. Jornada | 11.09.2021 | Seattle Sounders | - | Minnesota United FC | 1:0 | ||||
| 6. Jornada | 19.09.2021 | Real Salt Lake | - | Seattle Sounders | 1:0 | ||||
| 7. Jornada | 10.10.2021 | Seattle Sounders | - | Vancouver Whitecaps | 4:1 | |
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| 7. Jornada | 17.10.2021 | Houston Dynamo | - | Seattle Sounders | 2:1 | ||||
| 7. Jornada | 21.10.2021 | Colorado Rapids | - | Seattle Sounders | 1:1 | ||||
| 7. Jornada | 23.10.2021 | Seattle Sounders | - | Sporting Kansas City | 1:2 | |
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| 7. Jornada | 27.10.2021 | Los Angeles FC | - | Seattle Sounders | 3:0 | ||||
| 8. Jornada | 02.11.2021 | Seattle Sounders | - | Los Angeles Galaxy | 1:1 | ||||
| 8. Jornada | 08.11.2021 | Vancouver Whitecaps | - | Seattle Sounders | 1:1 |
Francia