| 1. Jornada | 04.06.2022 | San Lorenzo | - | Independiente | 1:1 | ||||
| 3. Jornada | 14.06.2022 | San Lorenzo | - | Arsenal de Sarandí | 3:3 | ||||
| 4. Jornada | 22.06.2022 | Central Córdoba SdE | - | San Lorenzo | 0:2 | ||||
| 5. Jornada | 26.06.2022 | San Lorenzo | - | Tigre | 1:1 | ||||
| 6. Jornada | 03.07.2022 | Barracas Central | - | San Lorenzo | 2:1 | ||||
| 7. Jornada | 09.07.2022 | San Lorenzo | - | Boca Juniors | 2:1 |  |
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| 8. Jornada | 17.07.2022 | Banfield | - | San Lorenzo | 1:1 | ||||
| 9. Jornada | 20.07.2022 | San Lorenzo | - | Unión de Santa Fe | 2:2 | ||||
| 11. Jornada | 30.07.2022 | Argentinos Juniors | - | San Lorenzo | 0:1 | ||||
| 12. Jornada | 07.08.2022 | San Lorenzo | - | Estudiantes | 0:0 | ||||
| 13. Jornada | 13.08.2022 | Patronato de Paraná | - | San Lorenzo | 3:2 | ||||
| 14. Jornada | 17.08.2022 | San Lorenzo | - | Platense | 2:0 | ||||
| 15. Jornada | 23.08.2022 | Racing Club | - | San Lorenzo | 1:2 | ||||
| 16. Jornada | 27.08.2022 | San Lorenzo | - | Rosario Central | 1:1 |
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