| 1. Jornada | 15.05.2021 | Montevideo Wanderers | - | Boston River | 1:0 | ||||
| 2. Jornada | 22.05.2021 | Boston River | - | Rentistas | 1:2 | ||||
| 3. Jornada | 30.05.2021 | Peñarol | - | Boston River | 5:2 |  |
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| 4. Jornada | 06.06.2021 | Boston River | - | Montevideo City Torque | 1:2 | ||||
| 10. Jornada | 11.07.2021 | Boston River | - | Cerro Largo | 1:0 | ||||
| 11. Jornada | 16.07.2021 | Progreso | - | Boston River | 1:0 | ||||
| 15. Jornada | 21.08.2021 | Deportivo Maldonado | - | Boston River | 0:2 |  |
Uruguay