| 1. Jornada | 07.01.2022 | Atlético San Luis | - | CF Pachuca | 0:2 |  |
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| 2. Jornada | 17.01.2022 | CF Pachuca | - | Deportivo Guadalajara | 2:1 | ||||
| 3. Jornada | 23.01.2022 | Club León | - | CF Pachuca | 2:1 | ||||
| 4. Jornada | 06.02.2022 | Club Necaxa | - | CF Pachuca | 1:3 | |
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| 5. Jornada | 15.02.2022 | CF Pachuca | - | Gallos Blancos | 2:2 | |
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| 6. Jornada | 20.02.2022 | CF América | - | CF Pachuca | 1:3 | |
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| 7. Jornada | 25.02.2022 | CF Pachuca | - | Mazatlán FC | 3:1 | |
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| 8. Jornada | 03.03.2022 | Atlas Guadalajara | - | CF Pachuca | 0:1 | ||||
| 10. Jornada | 13.03.2022 | Deportivo Toluca | - | CF Pachuca | 0:3 | |
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| 11. Jornada | 20.03.2022 | CF Pachuca | - | Cruz Azul | 1:0 | ||||
| 12. Jornada | 04.04.2022 | Santos Laguna | - | CF Pachuca | 3:1 | |
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| 9. Jornada | 08.04.2022 | CF Pachuca | - | UANL Tigres | 2:1 | ||||
| 13. Jornada | 12.04.2022 | CF Pachuca | - | Club Tijuana | 0:0 | ||||
| 14. Jornada | 16.04.2022 | FC Juárez | - | CF Pachuca | 1:2 | |
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| 15. Jornada | 20.04.2022 | CF Pachuca | - | Puebla FC | 1:0 | ||||
| 16. Jornada | 24.04.2022 | CF Pachuca | - | CF Monterrey | 3:0 |
Argentina
México 
