| 1. Jornada | 10.01.2022 | Deportivo Guadalajara | - | Mazatlán FC | 3:0 | ||||
| 3. Jornada | 22.01.2022 | Mazatlán FC | - | Deportivo Toluca | 1:2 | ||||
| 4. Jornada | 07.02.2022 | UANL Tigres | - | Mazatlán FC | 4:3 | ||||
| 5. Jornada | 12.02.2022 | Mazatlán FC | - | Club Tijuana | 2:0 | ||||
| 2. Jornada | 17.02.2022 | Mazatlán FC | - | CF América | 2:1 | ||||
| 6. Jornada | 20.02.2022 | Gallos Blancos | - | Mazatlán FC | 2:0 | ||||
| 7. Jornada | 25.02.2022 | CF Pachuca | - | Mazatlán FC | 3:1 | ||||
| 8. Jornada | 02.03.2022 | Mazatlán FC | - | Club Necaxa | 0:0 | ||||
| 10. Jornada | 12.03.2022 | CF Monterrey | - | Mazatlán FC | 2:1 | ||||
| 11. Jornada | 21.03.2022 | Mazatlán FC | - | Club León | 1:2 |  |
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| 9. Jornada | 27.03.2022 | Pumas UNAM | - | Mazatlán FC | 1:1 | ||||
| 12. Jornada | 02.04.2022 | Atlético San Luis | - | Mazatlán FC | 1:0 | ||||
| 13. Jornada | 09.04.2022 | Mazatlán FC | - | Cruz Azul | 1:1 | ||||
| 14. Jornada | 15.04.2022 | Atlas Guadalajara | - | Mazatlán FC | 1:2 | ||||
| 15. Jornada | 20.04.2022 | Mazatlán FC | - | Santos Laguna | 1:0 | ||||
| 16. Jornada | 23.04.2022 | FC Juárez | - | Mazatlán FC | 0:2 | ||||
| 17. Jornada | 30.04.2022 | Mazatlán FC | - | Puebla FC | 2:1 |
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