| 1. Jornada | 06.02.2022 | Club Aurora | - | CD Guabirá | 0:0 | ||||
| 2. Jornada | 12.02.2022 | Oriente Petrolero | - | Club Aurora | 2:0 | ||||
| 3. Jornada | 19.02.2022 | Club Aurora | - | Atlético Palmaflor | 1:2 |  |
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| 4. Jornada | 27.02.2022 | Universitario de Sucre | - | Club Aurora | 1:1 | |
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| 5. Jornada | 06.03.2022 | Real Santa Cruz | - | Club Aurora | 2:2 | |
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| 6. Jornada | 13.03.2022 | Club Aurora | - | Jorge Wilstermann | 1:0 | ||||
| 7. Jornada | 02.04.2022 | Nacional Potosí | - | Club Aurora | 2:1 | ||||
| 8. Jornada | 12.04.2022 | Club Aurora | - | The Strongest | 1:0 | |
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| 9. Jornada | 17.04.2022 | CD Guabirá | - | Club Aurora | 3:2 | |
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| 11. Jornada | 24.04.2022 | Atlético Palmaflor | - | Club Aurora | 0:1 | |
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| 12. Jornada | 30.04.2022 | Club Aurora | - | Universitario de Sucre | 3:0 | ||||
| 13. Jornada | 08.05.2022 | Jorge Wilstermann | - | Club Aurora | 0:0 | ||||
| 14. Jornada | 12.05.2022 | Club Aurora | - | Real Santa Cruz | 2:4 | ||||
| 15. Jornada | 15.05.2022 | Club Aurora | - | Nacional Potosí | 2:3 | |
Bolivia