| 1. Jornada | 18.04.2021 | D.C. United | - | New York City FC | 2:1 | ||||
| 1. Jornada | 25.04.2021 | New England Revolution | - | D.C. United | 1:0 | ||||
| 3. Jornada | 20.06.2021 | D.C. United | - | Inter Miami CF | 1:0 | ||||
| 3. Jornada | 24.06.2021 | CF Montréal | - | D.C. United | 0:0 | ||||
| 3. Jornada | 28.06.2021 | New York City FC | - | D.C. United | 2:1 |  |
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| 4. Jornada | 03.07.2021 | D.C. United | - | Toronto FC | 7:1 | |
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| 4. Jornada | 18.07.2021 | Philadelphia Union | - | D.C. United | 2:1 | ||||
| 4. Jornada | 22.07.2021 | Chicago Fire | - | D.C. United | 2:2 | ||||
| 4. Jornada | 26.07.2021 | D.C. United | - | New York RB | 1:0 | ||||
| 6. Jornada | 26.09.2021 | D.C. United | - | FC Cincinnati | 4:2 | |
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| 6. Jornada | 30.09.2021 | D.C. United | - | Minnesota United FC | 3:1 | ||||
| 7. Jornada | 03.10.2021 | Orlando City | - | D.C. United | 2:1 | ||||
| 7. Jornada | 17.10.2021 | D.C. United | - | Nashville SC | 0:0 | ||||
| 7. Jornada | 21.10.2021 | D.C. United | - | New England Revolution | 2:3 | |
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| 7. Jornada | 24.10.2021 | New York City FC | - | D.C. United | 6:0 | ||||
| 7. Jornada | 28.10.2021 | D.C. United | - | New York RB | 1:0 | ||||
| 7. Jornada | 31.10.2021 | D.C. United | - | Columbus Crew | 1:3 | ||||
| 8. Jornada | 07.11.2021 | Toronto FC | - | D.C. United | 1:3 |
Países Bajos