| 3. Jornada | 20.09.2021 | Anorthosis Famagusta | - | Ethnikos Achna | 2:1 | ||||
| 7. Jornada | 25.10.2021 | Anorthosis Famagusta | - | AEK Larnaca | 1:2 | ||||
| 8. Jornada | 29.10.2021 | Omonia Nikosia | - | Anorthosis Famagusta | 0:1 |  |
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| 9. Jornada | 07.11.2021 | Anorthosis Famagusta | - | Paphos FC | 1:0 | ||||
| 10. Jornada | 20.11.2021 | Olympiacos Nikosia | - | Anorthosis Famagusta | 3:2 | ||||
| 12. Jornada | 04.12.2021 | Anorthosis Famagusta | - | PAEEK | 2:3 | ||||
| 13. Jornada | 13.12.2021 | Anorthosis Famagusta | - | Doxa Katokopias | 2:0 | ||||
| 14. Jornada | 18.12.2021 | Ethnikos Achna | - | Anorthosis Famagusta | 0:2 |  |
Chipre