| 1. Jornada | 24.07.2021 | Botev Plovdiv | - | Pirin Blagoevgrad | 2:1 | ||||
| 2. Jornada | 02.08.2021 | Pirin Blagoevgrad | - | PFC Beroe | 2:3 | ||||
| 13. Jornada | 31.10.2021 | Pirin Blagoevgrad | - | Tsarsko Selo Sofia | 2:1 | ||||
| 14. Jornada | 06.11.2021 | Pirin Blagoevgrad | - | Botev Plovdiv | 0:1 | ||||
| 15. Jornada | 19.11.2021 | PFC Beroe | - | Pirin Blagoevgrad | 1:1 | ||||
| 16. Jornada | 27.11.2021 | Pirin Blagoevgrad | - | Lokomotiv Plovdiv | 2:3 | ||||
| 17. Jornada | 02.12.2021 | CSKA 1948 Sofia | - | Pirin Blagoevgrad | 1:0 |  |
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| 18. Jornada | 05.12.2021 | Pirin Blagoevgrad | - | CSKA Sofia | 1:1 | |
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| 19. Jornada | 13.12.2021 | PFC Ludogorets Razgrad | - | Pirin Blagoevgrad | 3:5 | ||||
| 20. Jornada | 21.02.2022 | Pirin Blagoevgrad | - | Lokomotiv Sofia | 2:1 | |
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| 24. Jornada | 20.03.2022 | Botev Vratsa | - | Pirin Blagoevgrad | 0:3 | ||||
| 25. Jornada | 03.04.2022 | Pirin Blagoevgrad | - | Levski Sofia | 0:3 | ||||
| 26. Jornada | 11.04.2022 | Tsarsko Selo Sofia | - | Pirin Blagoevgrad | 1:0 | |
Bulgaria