| 19. Jornada | 13.02.2022 | Makedonija GP | - | GFK Tikvesh | 1:0 |  |
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| 20. Jornada | 20.02.2022 | GFK Tikvesh | - | FK Pelister | 1:0 | ||||
| 21. Jornada | 27.02.2022 | KF Shkupi | - | GFK Tikvesh | 3:2 | ||||
| 22. Jornada | 05.03.2022 | GFK Tikvesh | - | FK Skopje | 3:0 | ||||
| 23. Jornada | 13.03.2022 | KF Shkëndija 79 | - | GFK Tikvesh | 2:1 | ||||
| 24. Jornada | 19.03.2022 | GFK Tikvesh | - | FK AP Brera Strumica | 1:2 | |
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| 25. Jornada | 03.04.2022 | KF Shkupi | - | GFK Tikvesh | 1:0 | ||||
| 26. Jornada | 06.04.2022 | GFK Tikvesh | - | FC Struga | 2:0 | |
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| 27. Jornada | 10.04.2022 | FK Rabotnički | - | GFK Tikvesh | 1:0 | ||||
| 28. Jornada | 17.04.2022 | FK Skopje | - | GFK Tikvesh | 1:2 | ||||
| 29. Jornada | 23.04.2022 | GFK Tikvesh | - | FK Borec | 5:0 | |
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| 30. Jornada | 01.05.2022 | FK Pelister | - | GFK Tikvesh | 1:1 | |
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| 32. Jornada | 08.05.2022 | FK Bregalnica Štip | - | GFK Tikvesh | 1:0 | ||||
| 33. Jornada | 15.05.2022 | GFK Tikvesh | - | Makedonija GP | 2:1 |  |
Bulgaria