| 4. Jornada | 26.09.2021 | Omonia Nikosia | - | Paphos FC | 1:1 | ||||
| 5. Jornada | 03.10.2021 | Olympiacos Nikosia | - | Omonia Nikosia | 1:0 | ||||
| 6. Jornada | 17.10.2021 | Omonia Nikosia | - | Apollon Limassol | 1:0 | ||||
| 7. Jornada | 25.10.2021 | PAEEK | - | Omonia Nikosia | 1:0 | ||||
| 8. Jornada | 29.10.2021 | Omonia Nikosia | - | Anorthosis Famagusta | 0:1 | ||||
| 11. Jornada | 26.12.2021 | APOEL Nikosia | - | Omonia Nikosia | 4:2 |  |
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| 15. Jornada | 05.01.2022 | Paphos FC | - | Omonia Nikosia | 1:1 | ||||
| 16. Jornada | 10.01.2022 | Omonia Nikosia | - | Olympiacos Nikosia | 1:0 | ||||
| 17. Jornada | 16.01.2022 | Apollon Limassol | - | Omonia Nikosia | 2:0 | ||||
| 18. Jornada | 24.01.2022 | Omonia Nikosia | - | PAEEK | 2:1 | ||||
| 19. Jornada | 29.01.2022 | Anorthosis Famagusta | - | Omonia Nikosia | 1:1 | ||||
| 20. Jornada | 07.02.2022 | Omonia Nikosia | - | Ethnikos Achna | 0:2 |
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