| 1. Jornada | 29.01.2023 | Guaireña FC | - | Club Nacional | 1:3 |  |
|||
| 2. Jornada | 03.02.2023 | Tacuary | - | Guaireña FC | 1:2 | ||||
| 3. Jornada | 12.02.2023 | Guaireña FC | - | Sportivo Trinidense | 1:1 | ||||
| 4. Jornada | 18.02.2023 | Guaireña FC | - | Cerro Porteño | 0:2 | ||||
| 5. Jornada | 27.02.2023 | Club Olimpia | - | Guaireña FC | 1:1 |  |
|||
| 6. Jornada | 03.03.2023 | Guaireña FC | - | General Caballero DJLM | 0:0 | |
|||
| 7. Jornada | 11.03.2023 | Libertad | - | Guaireña FC | 2:0 | ||||
| 15. Jornada | 29.04.2023 | Cerro Porteño | - | Guaireña FC | 2:0 | ||||
| 16. Jornada | 08.05.2023 | Guaireña FC | - | Club Olimpia | 1:0 | ||||
| 17. Jornada | 12.05.2023 | General Caballero DJLM | - | Guaireña FC | 3:0 | ||||
| 18. Jornada | 17.05.2023 | Guaireña FC | - | Libertad | 0:2 | ||||
| 19. Jornada | 22.05.2023 | Sportivo Ameliano | - | Guaireña FC | 1:1 |
Paraguay