| 1. Jornada | 23.11.2021 | Hyderabad FC | - | Chennaiyin FC | 0:1 | ||||
| 3. Jornada | 29.11.2021 | NorthEast United FC | - | Chennaiyin FC | 1:2 | ||||
| 7. Jornada | 18.12.2021 | Chennaiyin FC | - | Odisha FC | 2:1 | ||||
| 8. Jornada | 22.12.2021 | Chennaiyin FC | - | Kerala Blasters | 0:3 | ||||
| 12. Jornada | 13.01.2022 | Chennaiyin FC | - | Hyderabad FC | 1:1 | ||||
| 14. Jornada | 22.01.2022 | Chennaiyin FC | - | NorthEast United FC | 2:1 | ||||
| 15. Jornada | 26.01.2022 | Bengaluru FC | - | Chennaiyin FC | 3:0 | ||||
| 16. Jornada | 02.02.2022 | SC East Bengal | - | Chennaiyin FC | 2:2 |  |
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| 17. Jornada | 06.02.2022 | Chennaiyin FC | - | Mumbai City FC | 0:1 | ||||
| 18. Jornada | 09.02.2022 | Chennaiyin FC | - | FC Goa | 0:5 | ||||
| 21. Jornada | 16.02.2022 | Odisha FC | - | Chennaiyin FC | 2:2 | ||||
| 22. Jornada | 20.02.2022 | Chennaiyin FC | - | Jamshedpur FC | 1:4 | ||||
| 19. Jornada | 26.02.2022 | Kerala Blasters | - | Chennaiyin FC | 3:0 | ||||
| 20. Jornada | 03.03.2022 | Chennaiyin FC | - | ATK Mohun Bagan FC | 0:1 |
India