| 1. Jornada | 29.08.2021 | UCAM Murcia CF | - | UE Costa Brava | 1:1 | ||||
| 2. Jornada | 04.09.2021 | Betis B | - | UCAM Murcia CF | 1:0 | ||||
| 3. Jornada | 10.09.2021 | UCAM Murcia CF | - | Real Madrid Castilla | 3:0 | ||||
| 4. Jornada | 18.09.2021 | Linares Deportivo | - | UCAM Murcia CF | 1:2 | ||||
| 5. Jornada | 25.09.2021 | UCAM Murcia CF | - | FC Andorra | 1:1 | ||||
| 6. Jornada | 02.10.2021 | RB Linense | - | UCAM Murcia CF | 2:0 | ||||
| 8. Jornada | 15.10.2021 | CD Alcoyano | - | UCAM Murcia CF | 3:2 |  |
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| 9. Jornada | 23.10.2021 | UCAM Murcia CF | - | Sevilla Atlético | 2:1 |  |
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| 10. Jornada | 31.10.2021 | CE Sabadell | - | UCAM Murcia CF | 1:1 | |
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| 11. Jornada | 05.11.2021 | UCAM Murcia CF | - | Atlético Sanluqueño CF | 1:2 | ||||
| 13. Jornada | 21.11.2021 | Atlético Baleares | - | UCAM Murcia CF | 3:0 |
España