| 1. Jornada | 09.01.2022 | Pumas UNAM [Sub 20] | - | Deportivo Toluca [Sub 20] | 1:1 | ||||
| 2. Jornada | 14.01.2022 | Gallos Blancos [Sub 20] | - | Pumas UNAM [Sub 20] | 0:1 | ||||
| 3. Jornada | 23.01.2022 | Pumas UNAM [Sub 20] | - | UANL Tigres [Sub 20] | 2:1 |  |
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| 14. Jornada | 27.01.2022 | Pumas UNAM [Sub 20] | - | CF Monterrey [Sub 20] | 4:0 | ||||
| 4. Jornada | 06.02.2022 | Club Tijuana [Sub 20] | - | Pumas UNAM [Sub 20] | 1:1 | ||||
| 5. Jornada | 13.02.2022 | Pumas UNAM [Sub 20] | - | Club León [Sub 20] | 2:1 | |
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| 6. Jornada | 20.02.2022 | Atlas Guadalajara [Sub 20] | - | Pumas UNAM [Sub 20] | 0:0 | |
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| 7. Jornada | 26.02.2022 | Pumas UNAM [Sub 20] | - | CF América [Sub 20] | 0:1 | ||||
| 10. Jornada | 12.03.2022 | Cruz Azul [Sub 20] | - | Pumas UNAM [Sub 20] | 1:0 | ||||
| 11. Jornada | 19.03.2022 | Pumas UNAM [Sub 20] | - | Club Necaxa [Sub 20] | 1:2 | ||||
| 9. Jornada | 27.03.2022 | Pumas UNAM [Sub 20] | - | Mazatlán FC [Sub 20] | 3:0 |
México