| 1. Jornada | 11.03.2012 | Colorado Rapids | - | Columbus Crew | 2:0 |  |
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| 1. Jornada | 24.03.2012 | Columbus Crew | - | Impact de Montréal | 2:0 |  |
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| 1. Jornada | 31.03.2012 | Toronto FC | - | Columbus Crew | 0:1 | |
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| 2. Jornada | 07.04.2012 | Columbus Crew | - | New York RB | 1:4 | ||||
| 2. Jornada | 14.04.2012 | Philadelphia Union | - | Columbus Crew | 1:0 | ||||
| 2. Jornada | 22.04.2012 | Columbus Crew | - | Houston Dynamo | 2:2 | ||||
| 2. Jornada | 29.04.2012 | Columbus Crew | - | Vancouver Whitecaps | 0:1 | ||||
| 3. Jornada | 20.05.2012 | San Jose Earthquakes | - | Columbus Crew | 1:1 | ||||
| 4. Jornada | 24.06.2012 | Chicago Fire | - | Columbus Crew | 2:1 | ||||
| 5. Jornada | 15.07.2012 | Columbus Crew | - | Sporting Kansas City | 0:2 | ||||
| 7. Jornada | 23.09.2012 | Chicago Fire | - | Columbus Crew | 2:1 |
Costa Rica