| 1. Jornada | 30.01.2010 | Guaraní | - | Libertad | 1:0 | ||||
| 2. Jornada | 06.02.2010 | Libertad | - | Club Rubio Ñu | 2:1 | ||||
| 3. Jornada | 12.02.2010 | Tacuary | - | Libertad | 0:4 | ||||
| 5. Jornada | 21.02.2010 | Sportivo Trinidense | - | Libertad | 1:1 | ||||
| 6. Jornada | 01.03.2010 | Libertad | - | Sport Colombia | 3:0 | ||||
| 7. Jornada | 06.03.2010 | 3 de Febrero | - | Libertad | 0:0 |  |
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| 12. Jornada | 04.04.2010 | Libertad | - | Guaraní | 2:1 | ||||
| 13. Jornada | 10.04.2010 | Club Rubio Ñu | - | Libertad | 2:1 | ||||
| 15. Jornada | 18.04.2010 | Sportivo Luqueño | - | Libertad | 1:2 | ||||
| 14. Jornada | 22.04.2010 | Libertad | - | Tacuary | 0:0 | ||||
| 16. Jornada | 25.04.2010 | Libertad | - | Sportivo Trinidense | 0:1 |  |
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| 17. Jornada | 03.05.2010 | Sport Colombia | - | Libertad | 0:1 | |
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| 18. Jornada | 09.05.2010 | Libertad | - | 3 de Febrero | 3:0 | ||||
| 9. Jornada | 16.05.2010 | Cerro Porteño | - | Libertad | 0:2 | ||||
| 21. Jornada | 22.05.2010 | Club Olimpia | - | Libertad | 0:2 | ||||
| 20. Jornada | 27.05.2010 | Libertad | - | Cerro Porteño | 3:0 | |
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| 22. Jornada | 29.05.2010 | Libertad | - | Sol de América | 3:4 |  |
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| 19. Jornada | 01.06.2010 | Club Nacional | - | Libertad | 1:0 |
Uruguay