| 1. Jornada | 17.07.2010 | Sportivo Luqueño | - | Libertad | 1:2 | ||||
| 5. Jornada | 15.08.2010 | Club Olimpia | - | Libertad | 0:2 | ||||
| 13. Jornada | 09.10.2010 | Tacuary | - | Libertad | 0:1 | ||||
| 14. Jornada | 16.10.2010 | Libertad | - | Sport Colombia | 4:0 | ||||
| 16. Jornada | 24.10.2010 | Libertad | - | Club Olimpia | 2:2 | ||||
| 18. Jornada | 05.11.2010 | Guaraní | - | Libertad | 2:0 | ||||
| 22. Jornada | 05.12.2010 | Libertad | - | 3 de Febrero | 5:0 |  |
Uruguay