| 1. Jornada | 20.01.2008 | Cruz Azul | - | Santos Laguna | 1:1 | ||||
| 2. Jornada | 27.01.2008 | Santos Laguna | - | Deportivo Toluca | 2:2 |  |
|||
| 3. Jornada | 02.02.2008 | Veracruz (old) | - | Santos Laguna | 1:1 | ||||
| 5. Jornada | 14.02.2008 | Deportivo Guadalajara | - | Santos Laguna | 3:2 | ||||
| 7. Jornada | 24.02.2008 | CF América | - | Santos Laguna | 0:1 | ||||
| 8. Jornada | 02.03.2008 | Santos Laguna | - | CF Monterrey | 2:0 | ||||
| 9. Jornada | 09.03.2008 | Puebla FC | - | Santos Laguna | 3:3 | ||||
| 10. Jornada | 16.03.2008 | Santos Laguna | - | Jaguares Chiapas | 1:3 | ||||
| 11. Jornada | 23.03.2008 | Pumas UNAM | - | Santos Laguna | 1:1 | ||||
| 12. Jornada | 31.03.2008 | Santos Laguna | - | UAG Tecos | 4:0 | ||||
| 14. Jornada | 13.04.2008 | Santos Laguna | - | Atlas Guadalajara | 6:1 |  |
|||
| 17. Jornada | 04.05.2008 | Santos Laguna | - | Club San Luis | 4:1 |
México
