| 1. Jornada | 19.09.2021 | Lobos ULMX | - | Sporting Canamy | 0:0 | ||||
| 2. Jornada | 26.09.2021 | Yalmakan FC | - | Lobos ULMX | 1:0 |  |
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| 3. Jornada | 01.10.2021 | Inter Playa | - | Lobos ULMX | 3:1 | |
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| 5. Jornada | 13.10.2021 | Deportivo Dongu | - | Lobos ULMX | 2:2 | ||||
| 6. Jornada | 18.10.2021 | Lobos ULMX | - | Cañoneros FC | 2:3 | |
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| 8. Jornada | 31.10.2021 | Lobos ULMX | - | Escorpiones | 1:3 | ||||
| 9. Jornada | 06.11.2021 | Cafetaleros de Chiapas | - | Lobos ULMX | 1:2 | |
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| 10. Jornada | 11.11.2021 | Lobos ULMX | - | CD Zap | 1:2 | ||||
| 11. Jornada | 13.11.2021 | Inter de Querétaro | - | Lobos ULMX | 1:1 | ||||
| 12. Jornada | 21.11.2021 | Lobos ULMX | - | Montañeses FC | 3:2 | ||||
| 13. Jornada | 27.11.2021 | Leviatán FC | - | Lobos ULMX | 1:4 |
México