| 8. Jornada | 11.09.2021 | UANL Tigres [Sub 18] | - | Club León [Sub 18] | 1:1 | ||||
| 9. Jornada | 18.09.2021 | Club León [Sub 18] | - | FC Juárez [Sub 18] | 2:1 |  |
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| 12. Jornada | 02.10.2021 | Club León [Sub 18] | - | Atlético San Luis [Sub 18] | 4:3 | ||||
| 15. Jornada | 23.10.2021 | Puebla FC [Sub 18] | - | Club León [Sub 18] | 2:1 | ||||
| 16. Jornada | 31.10.2021 | Deportivo Toluca [Sub 18] | - | Club León [Sub 18] | 1:3 | ||||
| 17. Jornada | 06.11.2021 | Club León [Sub 18] | - | Club Necaxa [Sub 18] | 3:2 |
México