| 1. Jornada | 04.07.2022 | Atlético San Luis | - | Club León | 1:2 | ||||
| 3. Jornada | 16.07.2022 | Puebla FC | - | Club León | 1:1 | ||||
| 4. Jornada | 21.07.2022 | Deportivo Guadalajara | - | Club León | 0:0 |  |
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| 7. Jornada | 07.08.2022 | CF Monterrey | - | Club León | 5:1 | ||||
| 14. Jornada | 11.09.2022 | UANL Tigres | - | Club León | 0:1 | |
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| 17. Jornada | 03.10.2022 | Club León | - | Club Tijuana | 2:2 |
México