| 1. Jornada | 22.07.2012 | Santos Laguna | - | Club San Luis | 2:1 | ||||
| 2. Jornada | 30.07.2012 | Deportivo Guadalajara | - | Santos Laguna | 0:1 |  |
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| 3. Jornada | 04.08.2012 | Santos Laguna | - | Puebla FC | 2:2 | ||||
| 4. Jornada | 11.08.2012 | Club León | - | Santos Laguna | 3:0 | |
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| 5. Jornada | 19.08.2012 | Santos Laguna | - | Pumas UNAM | 1:2 | ||||
| 6. Jornada | 26.08.2012 | CF Pachuca | - | Santos Laguna | 0:0 | ||||
| 7. Jornada | 02.09.2012 | Santos Laguna | - | UANL Tigres | 3:1 | ||||
| 8. Jornada | 16.09.2012 | CF América | - | Santos Laguna | 2:0 | ||||
| 9. Jornada | 23.09.2012 | Santos Laguna | - | Jaguares Chiapas | 0:0 | ||||
| 10. Jornada | 01.10.2012 | Atlante | - | Santos Laguna | 1:3 | ||||
| 11. Jornada | 04.10.2012 | Santos Laguna | - | Atlas Guadalajara | 2:1 | ||||
| 12. Jornada | 07.10.2012 | Gallos Blancos (old) | - | Santos Laguna | 1:1 | ||||
| 13. Jornada | 14.10.2012 | Santos Laguna | - | Club Tijuana | 2:2 | ||||
| 14. Jornada | 21.10.2012 | Deportivo Toluca | - | Santos Laguna | 4:1 | ||||
| 15. Jornada | 28.10.2012 | CF Monterrey | - | Santos Laguna | 3:2 | ||||
| 16. Jornada | 03.11.2012 | Santos Laguna | - | Cruz Azul | 2:1 | |
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| 17. Jornada | 10.11.2012 | Monarcas Morelia | - | Santos Laguna | 2:0 | |
México