| 1. Jornada | 18.09.2021 | CF América [] | - | Cruz Azul [] | 4:2 | ||||
| 2. Jornada | 25.09.2021 | Gallos Blancos [] | - | CF América [] | 2:3 | ||||
| 5. Jornada | 16.10.2021 | CF América [] | - | Club Tijuana [] | 6:0 |  |
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| 3. Jornada | 20.10.2021 | CF América [] | - | Pumas UNAM [] | 3:2 |  |
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| 6. Jornada | 23.10.2021 | Cruz Azul [] | - | CF América [] | 2:2 | |
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| 7. Jornada | 30.10.2021 | CF América [] | - | Deportivo Toluca [] | 2:1 | ||||
| 8. Jornada | 06.11.2021 | CF Pachuca [] | - | CF América [] | 5:3 | ||||
| 9. Jornada | 13.11.2021 | CF América [] | - | Puebla FC [] | 6:1 | |
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| 10. Jornada | 20.11.2021 | FC Juárez [] | - | CF América [] | 1:2 |
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